CSF monoamine metabolites in relation to the diagnostic interview for borderline patients (DIB).
1998 (English)In: Neuropsychobiology, ISSN 0302-282X, E-ISSN 1423-0224, Vol. 38, no 4, 207-12 p.Article in journal (Refereed) Published
The cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol, and their ratios were studied in relation to the Diagnostic Interview for Borderline patients (DIB) evaluated retrospectively from hospital records for a sample of 202 patients participating in psychobiological programs on mood disorders. No correlations with the total DIB score were significant. Patients with borderline personality disorder (BPD) defined by a total DIB score of at least 7 or 6, respectively, did not differ significantly from non-BPD regarding the metabolites. However, for section II (impulse action pattern) of the DIB, those with an intermediate value of the section score had significantly higher levels of 5-HIAA and HVA, suggesting that such higher than normal concentrations may be protective against impulsive or suicidal behavior generated by an underlying psychiatric morbidity due to other risk factors.
Place, publisher, year, edition, pages
1998. Vol. 38, no 4, 207-12 p.
IdentifiersURN: urn:nbn:se:umu:diva-36401PubMedID: 9813458OAI: oai:DiVA.org:umu-36401DiVA: diva2:354053