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Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0003-1708-8259
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2002 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 109, no 5, 563-73 p.Article in journal (Refereed) Published
Abstract [en]

Fission yeast Cid13 and budding yeast Trf4/5 are members of a newly identified nucleotidyltransferase family conserved from yeast to man. Trf4/5 are thought to be essential DNA polymerases. We report that Cid13 is a poly(A) polymerase. Unlike conventional poly(A) polymerases, which act in the nucleus and indiscriminately polyadenylate all mRNA, Cid13 is a cytoplasmic enzyme that specifically targets suc22 mRNA that encodes a subunit of ribonucleotide reductase (RNR). cid13 mutants have reduced dNTP pools and are sensitive to hydroxyurea, an RNR inhibitor. We propose that Cid13 defines a cytoplasmic form of poly(A) polymerase important for DNA replication and genome maintenance.

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2002. Vol. 109, no 5, 563-73 p.
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URN: urn:nbn:se:umu:diva-36435PubMedID: 12062100OAI: oai:DiVA.org:umu-36435DiVA: diva2:354203
Available from: 2010-09-30 Created: 2010-09-30 Last updated: 2017-12-12

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Chabes, AndreiThelander, Lars

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