Change search
ReferencesLink to record
Permanent link

Direct link
Age-correlated decline in [3H]tiagabine binding to GAT-1 in human frontal cortex.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
2006 (English)In: Aging Clinical and Experimental Research, ISSN 1594-0667, Vol. 18, no 3, 257-60 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND AIMS: In spite of the fact that GABA is a significant transmitter, little is known about the GABA system in aging, compared with other transmitter systems. [(3)H]tiagabine is a ligand for GABAergic neurons, which binds with 10-fold higher affinity to the GABA uptake site than [(3)H]nipecotic acid. The aim of this study was to study the binding of [(3)H]tiagabine to the GABA transporter 1, GAT-1, in human frontal cortex and cingulate cortex from individuals of varying ages. METHODS: [(3)H]tiagabine binding experiments were conducted on post-mortem brain tissue from 19 individuals (age range 17-78 years) without known neurological or psychiatric disorders. Binding data vs age and postmortem interval was analysed by Pearson correlation. RESULTS: The density of [(3)H]tiagabine binding to GAT- 1 decreased significantly with increasing age in the frontal cortex, whereas binding affinity was unchanged. No significant alterations in binding parameters were observed in the cingulate cortex. No correlation was found between post-mortem delay and the number of [(3)H]tiagabine binding sites. CONCLUSIONS: According to the present study, presynaptical alterations in the GABA system are correlated with aging in the frontal cortex of the human brain. Further studies involving a broader range of brain regions seem warranted, to confirm the present findings and to enlarge knowledge about the GABA system in aging.

Place, publisher, year, edition, pages
2006. Vol. 18, no 3, 257-60 p.
URN: urn:nbn:se:umu:diva-36476PubMedID: 16804373OAI: diva2:354252
Available from: 2010-09-30 Created: 2010-09-30 Last updated: 2011-05-17

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Allard, Per
By organisation
In the same journal
Aging Clinical and Experimental Research

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link