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Unaltered [3H]GBR-12935 binding after chronic treatment with dopamine active drugs.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
1990 (English)In: Psychopharmacology, ISSN 0033-3158, E-ISSN 1432-2072, Vol. 102, no 3, 291-4 p.Article in journal (Refereed) Published
Abstract [en]

Rats were injected intraperitoneally with haloperidol 0.5 mg/kg, raclopride 1 mg/kg, bromocriptine 2.5 mg/kg, d-amphetamine 2.5 mg/kg, or cocaine 10 mg/kg twice daily for 21 days. The animals were sacrificed 72 h after last injection. Control rats were injected with saline, following the same schedule. The radioligand [3H]GBR-12935 was used as a presynaptic marker for dopamine neurites. There were no significant differences in [3H]GBR-12935 binding to striatum between drug-treated rats and controls.

Place, publisher, year, edition, pages
1990. Vol. 102, no 3, 291-4 p.
Identifiers
URN: urn:nbn:se:umu:diva-36540PubMedID: 1979175OAI: oai:DiVA.org:umu-36540DiVA: diva2:354632
Available from: 2010-10-04 Created: 2010-10-04 Last updated: 2017-12-12

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