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Circulating vitamin d and risk of epithelial ovarian cancer
Department of Environmental Medicine, New York University School of Medicine.
Department of Environmental Medicine, New York University School of Medicine.
Department of Environmental Medicine, New York University School of Medicine.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
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2009 (English)In: Journal of oncology, ISSN 1687-8450, Vol. 2009, 672492-672500 p.Article in journal (Refereed) Published
Abstract [en]

We conducted a nested case-control study within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Health and Disease Study, to examine the association between prediagnostic circulating levels of 25-hydroxy vitamin D (25(OH)D) and the risk of subsequent invasive epithelial ovarian cancer (EOC). The 25(OH)D levels were measured in serum or plasma from 170 incident cases of EOC and 373 matched controls. Overall, circulating 25(OH)D levels were not associated with the risk of EOC in combined cohort analysis: adjusted OR for the top tertile versus the reference tertile, 1.09 (95% CI, 0.59-2.01). In addition, there was no evidence of an interaction effect between VDR SNP genotype or haplotype and circulating 25(OH)D levels in relation to ovarian cancer risk, although more complex gene-environment interactions may exist.

Place, publisher, year, edition, pages
2009. Vol. 2009, 672492-672500 p.
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-36649DOI: 10.1155/2009/672492PubMedID: 19727412OAI: oai:DiVA.org:umu-36649DiVA: diva2:355464
Available from: 2010-10-06 Created: 2010-10-06 Last updated: 2015-04-22Bibliographically approved

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Hultdin, JohanEnquist, KerstinÅgren, ÅsaSjodin, HubertHallmans, GöranLundin, Eva
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