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Breastfeeding enhances the antibody response to Hib and Pneumococcal serotype 6B and 14 after vaccination with conjugate vaccines
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Department of Paediatrics, Örebro University Hospital, Örebro, Sweden.
Clinical Research Centre, Biostatistics and Epidemiology Unit, Örebro University Hospital, Örebro, Sweden.
2007 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 25, no 8, 1497-1502 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: This study was performed in order to investigate the relationship between breastfeeding and the antibody response after vaccination with conjugate vaccines against Hib and pneumococcal diseases. METHODS: This was an open non-randomised multi-centre study enrolling 101 healthy Swedish infants. PncCRM was administered concomitantly with DTaP/IPV/Hib at 3, 5, and 12 months at separate site. Duration of breastfeeding was calculated for days of almost exclusive as well as of total (any form of) breastfeeding. RESULTS: At 13 months of age 6 out of 83 children did not reach 0.2mug/ml against serotype 6B, and five of these were breastfed less than 90 days (Fisher's Exact test, P=0.011). Four children did not reach 1mug/ml against Hib and all those were breastfed less than 90 days (Fisher's Exact test, P=0.008). One month after the second dose, at 6 months of age, children breastfed 90 days or more showed significantly higher GMC against serotype 14 (P=0.003). CONCLUSION: This study indicates that children exclusively breastfed 90 days or more might get a better serological protection against Hib, and the pneumococcal serotypes 6B and 14 after vaccination, compared to children less breastfed.

Place, publisher, year, edition, pages
2007. Vol. 25, no 8, 1497-1502 p.
Keyword [en]
Breastfeeding; Hib; Pneumococcus; Antibody response; Vaccination
Identifiers
URN: urn:nbn:se:umu:diva-36700DOI: 10.1016/j.vaccine.2006.10.025PubMedID: 17097198OAI: oai:DiVA.org:umu-36700DiVA: diva2:355800
Available from: 2010-10-08 Created: 2010-10-08 Last updated: 2017-12-12Bibliographically approved

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CiteExportLink to record
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