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Safety and immunogenicity of a combined DTPa-IPV vaccine administered as a booster from 4 years of age: a review
GlaxoSmithKline Biologicals, Rixensart, Belgium.
Hôpital d’enfants Armand Trousseau, Paris, France.
Hôpital d’enfants Armand Trousseau, Paris, France.
Hôpital Intercommunal de Créteil, France.
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2006 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 24, no 13, 2440-2448 p.Article in journal (Refereed) Published
Abstract [en]

A combined DTPa-IPV booster vaccine was administered as a 4th or 5th dose after DTPa or DTPw priming. Over 99% vaccines developed antibody levels considered to be protective to diphtheria, tetanus and poliovirus, and >95% mounted a response to acellular pertussis antigens. Rectal temperature >39.5 degrees C was observed in at most 3.2% of vaccinees. Swelling >50 mm occurred in 24% of DTPa-primed compared to 5.5% of DTPw-primed children. Large swelling involving the entire upper arm (extending to involve the elbow joint) was reported for up to 1.2% of DTPa-primed subjects, which is consistent with literature reports for other DTPa vaccines.

Place, publisher, year, edition, pages
2006. Vol. 24, no 13, 2440-2448 p.
Keyword [en]
Immunogenicity; Vaccine-associated adverse events; Acellular pertussis vaccine; Booster vaccination
URN: urn:nbn:se:umu:diva-36701DOI: 10.1016/j.vaccine.2005.12.009PubMedID: 16406224OAI: diva2:355805
Available from: 2010-10-08 Created: 2010-10-08 Last updated: 2010-10-12Bibliographically approved

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