Safety and immunogenicity of a combined DTPa-IPV vaccine administered as a booster from 4 years of age: a review
2006 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 24, no 13, 2440-2448 p.Article in journal (Refereed) Published
A combined DTPa-IPV booster vaccine was administered as a 4th or 5th dose after DTPa or DTPw priming. Over 99% vaccines developed antibody levels considered to be protective to diphtheria, tetanus and poliovirus, and >95% mounted a response to acellular pertussis antigens. Rectal temperature >39.5 degrees C was observed in at most 3.2% of vaccinees. Swelling >50 mm occurred in 24% of DTPa-primed compared to 5.5% of DTPw-primed children. Large swelling involving the entire upper arm (extending to involve the elbow joint) was reported for up to 1.2% of DTPa-primed subjects, which is consistent with literature reports for other DTPa vaccines.
Place, publisher, year, edition, pages
2006. Vol. 24, no 13, 2440-2448 p.
Immunogenicity; Vaccine-associated adverse events; Acellular pertussis vaccine; Booster vaccination
IdentifiersURN: urn:nbn:se:umu:diva-36701DOI: 10.1016/j.vaccine.2005.12.009PubMedID: 16406224OAI: oai:DiVA.org:umu-36701DiVA: diva2:355805