Invasive Haemophilus influenzae disease: epidemiology and clinical spectrum before large-scale H. influenzae type b vaccination
1995 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 27, no 1, 63-67 p.Article in journal (Refereed) Published
In a prospective study between January 1987 and December 1992, 103 patients with invasive Haemophilus influenzae (Hi) infection were identified in a well-defined population before large-scale Haemophilus influenzae type b (Hib) vaccination was introduced. The incidence (case/100,000/year) of invasive Hi infection was 5.9 for the whole population, 55 for children 0-4 years old and as high as 2.8 for adults. Hib was the predominant cause of the infection (83 cases) in children but, in adults, 13/39 (30%) cases were caused by non-typable Hi and 6/39 (19%) by Hi serotype f. Three patients (3%) died and 6 (5.8%) suffered a permanent sequel from the infection. All patients with such a sequel had invasive Hib infection. No significant difference between patients 0-6 years old and matched controls regarding the frequency of subnormal serum levels of immunoglobulins was found.
Place, publisher, year, edition, pages
1995. Vol. 27, no 1, 63-67 p.
IdentifiersURN: urn:nbn:se:umu:diva-36911PubMedID: 7784816OAI: oai:DiVA.org:umu-36911DiVA: diva2:356673