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Invasive Haemophilus influenzae disease: epidemiology and clinical spectrum before large-scale H. influenzae type b vaccination
Departments of Otorhinolaryngology, Örebro Medical Center Hospital, Örebro, Sweden.
Departments of Paediatrics, Örebro Medical Center Hospital, Örebro, Sweden.
Departments of Clinical Microbiology and Immunology, Örebro Medical Center Hospital, Örebro, Sweden.
Departments of Paediatrics, Örebro Medical Center Hospital, Örebro, Sweden.
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1995 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 27, no 1, 63-67 p.Article in journal (Refereed) Published
Abstract [en]

In a prospective study between January 1987 and December 1992, 103 patients with invasive Haemophilus influenzae (Hi) infection were identified in a well-defined population before large-scale Haemophilus influenzae type b (Hib) vaccination was introduced. The incidence (case/100,000/year) of invasive Hi infection was 5.9 for the whole population, 55 for children 0-4 years old and as high as 2.8 for adults. Hib was the predominant cause of the infection (83 cases) in children but, in adults, 13/39 (30%) cases were caused by non-typable Hi and 6/39 (19%) by Hi serotype f. Three patients (3%) died and 6 (5.8%) suffered a permanent sequel from the infection. All patients with such a sequel had invasive Hib infection. No significant difference between patients 0-6 years old and matched controls regarding the frequency of subnormal serum levels of immunoglobulins was found.

Place, publisher, year, edition, pages
1995. Vol. 27, no 1, 63-67 p.
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URN: urn:nbn:se:umu:diva-36911PubMedID: 7784816OAI: oai:DiVA.org:umu-36911DiVA: diva2:356673
Available from: 2010-10-13 Created: 2010-10-13 Last updated: 2017-12-12Bibliographically approved

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Silfverdal, Sven Arne
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