Change search
ReferencesLink to record
Permanent link

Direct link
Efficacy of desmopressin (Minirin) in the treatment of nocturia: a double-blind placebo-controlled study in women
Department of Gynecology, Glostrup Hospital, Glostrup, Denmark.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynaecology.
Department of Obstetrics and Gynaecology, Derriford Hospital, Plymouth, United Kingdom.
Department of Urology, University Hospital Maastricht, Maastricht, The Netherlands.
2003 (English)In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 189, no 4, 1106-1113 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The purpose of this study was to investigate the efficacy and safety of oral desmopressin in the treatment of nocturia in women.

STUDY DESIGN: Women aged 18 years or older with nocturia (>or=2 voids per night with a nocturia index score >1) received desmopressin (0.1 mg, 0.2 mg, or 0.4 mg) during a 3-week dose-titration period. After a 1-week washout period, patients who responded in this period received desmopressin or placebo in a double-blind fashion for 3 weeks.

RESULTS: In double-blind phase, 144 patients were randomly assigned to groups (desmopressin, n=72; placebo, n=72). For desmopressin, 33 (46%) patients had a 50% or greater reduction in nocturnal voids against baseline levels compared with 5 (7%) patients receiving placebo (P<.0001). The mean number of nocturnal voids, duration of sleep until the first nocturnal void, nocturnal diuresis, and ratios of nocturnal per 24 hours and nocturnal per daytime urine volumes changed significantly in favor of desmopressin versus placebo (P<.0001). In the dose-titration phase headache (22%), nausea (8%), and hyponatremia (6%) were reported. Two deaths occurred, although neither could be directly associated with the study drug.

CONCLUSION: Oral desmopressin is an effective and well-tolerated treatment for nocturia in women.

Place, publisher, year, edition, pages
2003. Vol. 189, no 4, 1106-1113 p.
Keyword [en]
Arginine vasopressin; desmopressin; nocturia; nocturnal polyuria
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
URN: urn:nbn:se:umu:diva-36923DOI: 10.1067/S0002-9378(03)00593-3PubMedID: 14586363OAI: diva2:356819
Available from: 2010-10-14 Created: 2010-10-14 Last updated: 2011-04-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lalos, Othon
By organisation
Obstetrics and Gynaecology
In the same journal
American Journal of Obstetrics and Gynecology
Obstetrics, Gynecology and Reproductive Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 21 hits
ReferencesLink to record
Permanent link

Direct link