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A randomized trial of basing treatment on human papillomavirus and/or cytology results in low-grade cervical lesion triage
Department of Obstetrics and Gynecology, Central Hospital, Karlstad, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynaecology.
Department of Medical Microbiology, Lund University, University Hospital at Malmö, Malmö, Sweden.
Department of Pathology, Norwegian National Hospital, University of Oslo, Oslo, Norway.
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2008 (English)In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 199, no 1, 24.e1-24.e7 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: This study was undertaken to compare management algorithms that base treatment with loop electrosurgical excision procedure on human papillomavirus and/or repeat Papanicolaou test smear results.

STUDY DESIGN: A randomized trial that referred 674 women with either atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions cytology results, detected in organized screening to treatment either (1) if they were positive in a repeat Papanicolaou test smear and/or a human papillomavirus test or (2) if they were positive in the repeat Papanicolaou test smear test only. Women who tested positive were treated, regardless of colposcopic findings.

RESULTS: There were 208 of 337 (62%) women who were treated in the human papillomavirus /Papanicolaou test smear group (187/337 because of HPV positivity) and 138 of 337 (41%) in the Papanicolaou test smear only group. Histopathologically diagnosed cervical intraepithelial neoplasia grade 2 or worse was found among 112 of 337 (33.2%) women in the human papillomavirus/Papanicolaou test smear group compared with 85 of 337 (25.2%) women in the Papanicolaou test smear only group (P < .05). Twenty-one women with cervical intraepithelial neoplasia 2+ had normal colposcopy.

CONCLUSION: For adequate cervical intraepithelial neoplasia 2+ sensitivity, the decision to use loop electrosurgical excision procedure needs to be based on human papillomavirus testing results and should not exclude women with normal colposcopy.

Place, publisher, year, edition, pages
2008. Vol. 199, no 1, 24.e1-24.e7 p.
Keyword [en]
atypical squamous cells of undetermined significance; cervical intraepithelial neoplasia; colposcopy; loop electrosurgical excision procedure; randomized trial
URN: urn:nbn:se:umu:diva-37045DOI: 10.1016/j.ajog.2007.11.053PubMedID: 18295172OAI: diva2:357605
Available from: 2010-10-19 Created: 2010-10-19 Last updated: 2011-04-01Bibliographically approved

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