Imaging of the guinea pig cochlea following round window gadolinium application
2004 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 15, no 12, 1927-1930 p.Article in journal (Refereed) Published
Precise, non-invasive determination of the aetiology and site of pathology of inner ear disorders is difficult. The aim of this study was to describe an alternative method for inner ear visualization, based on local application of the paramagnetic contrast agent gadolinium. Using a 4.7 T MRI scanner, high contrast images of all four cochlear turns were obtained 3.5 h after placing gadolinium on the round window membrane. Gadolinium cleared from the cochlea within 96 h. Auditory brainstem response measurements performed on a separate group of animals showed no significant threshold shifts after the application, indicating that gadolinium is non-toxic to the guinea pig cochlea.
Place, publisher, year, edition, pages
2004. Vol. 15, no 12, 1927-1930 p.
Gadolinium, Guinea pig, Hearing, Inner ear, MRI, Round window membrane
IdentifiersURN: urn:nbn:se:umu:diva-37175PubMedID: 15305139OAI: oai:DiVA.org:umu-37175DiVA: diva2:358228