Change search
ReferencesLink to record
Permanent link

Direct link
Statistical methods for clinical verification of dose-response parameters related to esophageal stricture and AVM obliteration from radiotherapy
Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Sweden .
Department of Medical Radiation Physics, Karolinska Institutet and Stockholm University, Sweden .
Department of Medical Physics, Larissa University Hospital, Larissa, Greece .
Department of Otolaryngology, Head and Neck Surgery, Karolinska Hospital, Stockholm, Sweden .
Show others and affiliations
2004 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 49, no 16, 3797-3816 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of this work is to provide some statistical methods for evaluating the predictive strength of radiobiological models and the validity of dose-response parameters for tumour control and normal tissue complications. This is accomplished by associating the expected complication rates, which are calculated using different models, with the clinical follow-up records. These methods are applied to 77 patients who received radiation treatment for head and neck cancer and 85 patients who were treated for arteriovenous malformation (AVM). The three-dimensional dose distribution delivered to esophagus and AVM nidus and the clinical follow-up results were available for each patient. Dose-response parameters derived by a maximum likelihood fitting were used as a reference to evaluate their compatibility with the examined treatment methodologies. The impact of the parameter uncertainties on the dose-response curves is demonstrated. The clinical utilization of the radiobiological parameters is illustrated. The radiobiological models (relative seriality and linear Poisson) and the reference parameters are validated to prove their suitability in reproducing the treatment outcome pattern of the patient material studied (through the probability of finding a worse fit, area under the ROC curve and chi2 test). The analysis was carried out for the upper 5 cm of the esophagus (proximal esophagus) where all the strictures are formed, and the total volume of AVM. The estimated confidence intervals of the dose-response curves appear to have a significant supporting role on their clinical implementation and use.

Place, publisher, year, edition, pages
2004. Vol. 49, no 16, 3797-3816 p.
URN: urn:nbn:se:umu:diva-37176DOI: 10.1088/0031-9155/49/16/023PubMedID: 15446806OAI: diva2:358230
Available from: 2010-10-21 Created: 2010-10-21 Last updated: 2010-11-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Laurell, Göran
In the same journal
Physics in Medicine and Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 19 hits
ReferencesLink to record
Permanent link

Direct link