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Nanomolar concentrations of lysophosphatidylcholine recruit monocytes and induce pro-inflammatory cytokine production in macrophages
aDepartment of Clinical Sciences, Experimental Cardiovascular Research, CRC Lund University, Malmö University Hospital, Malmö, Sweden.
aDepartment of Clinical Sciences, Experimental Cardiovascular Research, CRC Lund University, Malmö University Hospital, Malmö, Sweden.
aDepartment of Clinical Sciences, Experimental Cardiovascular Research, CRC Lund University, Malmö University Hospital, Malmö, Sweden.
aDepartment of Clinical Sciences, Experimental Cardiovascular Research, CRC Lund University, Malmö University Hospital, Malmö, Sweden.
2008 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 370, no 2, 348-352 p.Article in journal (Refereed) Published
Abstract [en]

Lysophosphatidylcholine (LPC) has been attributed a pro-inflammatory role in atherosclerosis. Cell culture studies have identified stimulation of cytokine expression and chemotaxis by micromolar (muM) concentrations of LPC. In the present study we have investigated if LPC, in similarity with many other lipid mediators, has pro-inflammatory effects also at nanomolar (nM) concentrations. Cultured mouse bone marrow derived and RAW264.7 macrophages exposed to LPC demonstrated two peaks of increased MIP-2 release and mRNA expression; one at 0.1-10nM and another at muM concentrations. Both concentration ranges of LPC were also found to stimulate THP-1 monocyte chemotaxis. However, stimulation of the cells with muM concentrations of LPC may cause cell injury as increased release of lactate dehydrogenase was observed. Our findings demonstrate two peaks of LPC-induced pro-inflammatory activity, one in the nM and one in the muM range, and indicate that the latter may involve a stress response to lipid cytotoxicity.

Place, publisher, year, edition, pages
2008. Vol. 370, no 2, 348-352 p.
Keyword [en]
Lysophosphatidylcholine; Atherosclerosis; Inflammation; Chemotaxis; Monocyte/macrophages
Identifiers
URN: urn:nbn:se:umu:diva-37220DOI: 10.1016/j.bbrc.2008.03.087PubMedID: 18371300OAI: oai:DiVA.org:umu-37220DiVA: diva2:358409
Available from: 2010-10-21 Created: 2010-10-21 Last updated: 2017-12-12Bibliographically approved

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