In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia
2011 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 35, no 4, 472-478 p.Article in journal (Refereed) Published
Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD <0.1% day 29. The risk of any relapse was correlated to vincristine and doxorubicin resistance, with a relative risk of 3.7 (95% CI 1.3-10.5; p=0.016) for patients resistant to both drugs. There was a significant correlation also for the subgroup with extra-medullary relapses. Our findings indicate that analysis of drug resistance can add prognostic information to other known risk-factors including MRD.
Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 35, no 4, 472-478 p.
acute lymphoblastic leukemia, childhood, in vitro drug resistance, MRD, prognostic factors
Cancer and Oncology
IdentifiersURN: urn:nbn:se:umu:diva-37379DOI: 10.1016/j.leukres.2010.09.001PubMedID: 20961616OAI: oai:DiVA.org:umu-37379DiVA: diva2:359898