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In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
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2011 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 35, no 4, 472-478 p.Article in journal (Refereed) Published
Abstract [en]

Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD <0.1% day 29. The risk of any relapse was correlated to vincristine and doxorubicin resistance, with a relative risk of 3.7 (95% CI 1.3-10.5; p=0.016) for patients resistant to both drugs. There was a significant correlation also for the subgroup with extra-medullary relapses. Our findings indicate that analysis of drug resistance can add prognostic information to other known risk-factors including MRD.

Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 35, no 4, 472-478 p.
Keyword [en]
acute lymphoblastic leukemia, childhood, in vitro drug resistance, MRD, prognostic factors
National Category
Cancer and Oncology
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URN: urn:nbn:se:umu:diva-37379DOI: 10.1016/j.leukres.2010.09.001PubMedID: 20961616OAI: oai:DiVA.org:umu-37379DiVA: diva2:359898
Available from: 2010-11-01 Created: 2010-11-01 Last updated: 2017-12-12Bibliographically approved

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