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Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2010 (English)In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1090-2120, Vol. 20, no 23, 6925-6928 p.Article in journal (Refereed) Published
Abstract [en]

The synthesis of a series of novel macrocyclic compounds designed to target blood coagulation Factor XIa is described. The compounds were evaluated for their inhibition of a small set of serine proteases. Several compounds displayed modest activity and good selectivity for Factor XIa. Within the series, a promising lead structure for developing novel macrocyclic inhibitors of thrombin was identified.

Place, publisher, year, edition, pages
Elsevier Ltd , 2010. Vol. 20, no 23, 6925-6928 p.
Keyword [en]
Enzyme inhibitor, Thrombin, Macrocycle
Identifiers
URN: urn:nbn:se:umu:diva-38058DOI: 10.1016/j.bmcl.2010.09.141ISI: 000283801400010PubMedID: 21035339OAI: oai:DiVA.org:umu-38058DiVA: diva2:372080
Available from: 2010-11-24 Created: 2010-11-24 Last updated: 2017-12-12Bibliographically approved

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