Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa
2010 (English)In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1464-3405, Vol. 20, no 23, 6925-6928 p.Article in journal (Refereed) Published
The synthesis of a series of novel macrocyclic compounds designed to target blood coagulation Factor XIa is described. The compounds were evaluated for their inhibition of a small set of serine proteases. Several compounds displayed modest activity and good selectivity for Factor XIa. Within the series, a promising lead structure for developing novel macrocyclic inhibitors of thrombin was identified.
Place, publisher, year, edition, pages
Elsevier Ltd , 2010. Vol. 20, no 23, 6925-6928 p.
Enzyme inhibitor, Thrombin, Macrocycle
IdentifiersURN: urn:nbn:se:umu:diva-38058DOI: 10.1016/j.bmcl.2010.09.141ISI: 000283801400010PubMedID: 21035339OAI: oai:DiVA.org:umu-38058DiVA: diva2:372080