Cannulation of the noncalcified aorta generates particles of microembolic nature: an experimental study using pig aorta
2008 (English)In: Journal of cardiac surgery, ISSN 0886-0440, E-ISSN 1540-8191, Vol. 23, no 1, 39-43 p.Article in journal (Refereed) Published
BACKGROUND AND AIM OF THE STUDY: Aortic cannulation during cardiac surgery is a potential etiological factor for perioperative stroke. Cannulae may dislodge aortic-wall calcifications. In addition, the sharp edge of the cannula-tip may shear off vessel-wall tissue, which can be expelled into the lumen. This hypothesis concerning source of emboli was tested in a noncalcified aortic perfusion model.
METHODS: Pig aortas were pressurized and cannulated. Washout samples were collected before and after cannulation (n = 40). Particles were deposited onto a 10-microm filter and evaluated by microscopy and digital image analysis.
RESULTS: A higher incidence of particles generated by cannulation was noted as compared to before the maneuver (p < 0.001). This increase included small (<0.1 mm, p < 0.001) and intermediate-size particles (0.1-0.5 mm, p < 0.001). Particles above 0.5 mm were few and were not associated with cannulation.
CONCLUSIONS: Cannulation was a source of embolic material in the noncalcified aortic model. However, these particles were less than 0.5 mm in diameter and may contribute to neurocognitive decline after cardiac surgery.
Place, publisher, year, edition, pages
2008. Vol. 23, no 1, 39-43 p.
aorta and great vessels, cardiovascular research, perfusion
Research subject Thoracic and Cardivascular Suregery
IdentifiersURN: urn:nbn:se:umu:diva-38076DOI: 10.1111/j.1540-8191.2007.00481.xOAI: oai:DiVA.org:umu-38076DiVA: diva2:372214