umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Vorinostat-like molecules as structural, stereochemical, and pharmacological tools
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Show others and affiliations
2010 (English)In: ACS Medicinal Chemical Letters, ISSN 1948-5875, Vol. 1, no 2, 70-74 p.Article in journal (Refereed) Published
Abstract [en]

The inhibitory activity of an ω-alkoxy analogue of the HDAC inhibitor, Vorinostat (SAHA), against the 11 isoforms of HDAC is described and evaluated with regard to structural biology information retrieved through computational methods. Preliminary absorption and metabolism studies were performed, which positioned this compound as a potential candidate for further preclinical studies and delineated measures for improving its pharmacokinetic profile.

Place, publisher, year, edition, pages
American Chemical Society , 2010. Vol. 1, no 2, 70-74 p.
Keyword [en]
HDAC promiscuous inhibitors, SAHA analogues, HDAC1-11 profile, class IIa-specific profile, absorption and metabolism
Identifiers
URN: urn:nbn:se:umu:diva-38185DOI: 10.1021/ml100028gISI: 000281134500005OAI: oai:DiVA.org:umu-38185DiVA: diva2:372793
Available from: 2010-11-29 Created: 2010-11-29 Last updated: 2010-12-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Larsson, Andreas

Search in DiVA

By author/editor
Larsson, Andreas
By organisation
Department of Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 78 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf