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Vorinostat-like molecules as structural, stereochemical, and pharmacological tools
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2010 (English)In: ACS Medicinal Chemical Letters, ISSN 1948-5875, Vol. 1, no 2, 70-74 p.Article in journal (Refereed) Published
Abstract [en]

The inhibitory activity of an ω-alkoxy analogue of the HDAC inhibitor, Vorinostat (SAHA), against the 11 isoforms of HDAC is described and evaluated with regard to structural biology information retrieved through computational methods. Preliminary absorption and metabolism studies were performed, which positioned this compound as a potential candidate for further preclinical studies and delineated measures for improving its pharmacokinetic profile.

Place, publisher, year, edition, pages
American Chemical Society , 2010. Vol. 1, no 2, 70-74 p.
Keyword [en]
HDAC promiscuous inhibitors, SAHA analogues, HDAC1-11 profile, class IIa-specific profile, absorption and metabolism
URN: urn:nbn:se:umu:diva-38185DOI: 10.1021/ml100028gISI: 000281134500005OAI: diva2:372793
Available from: 2010-11-29 Created: 2010-11-29 Last updated: 2010-12-02Bibliographically approved

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Larsson, Andreas
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