1:1 and 2:1 urea-Succinic acid cocrystals: structural diversity, solution chemistry, and thermodynamic stability
2010 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 10, no 11, 4847-4855 p.Article in journal (Refereed) Published
The aim of this work was to study the crystal structures of 1:1 and 2:1 urea-succinic acid (U-SA) cocrystals and to investigate the role of solution chemistry in the formation and stability of different stoichiometric cocrystals. The structural diversity of other urea-dicarboxylic acid cocrystals is also discussed. The 1:1 U-SA cocrystal was stabilized by an acid-amide heterosynthon while acid-amide heterosynthons and amide amide homosynthons stabilized the 2:1 cocrystals. The hydrogen bonding motifs 1:1 and 2:1 U-SA cocrystals were consistent with other urea-dicarboxylic acid systems with similar stoichiometrics. The 1:1 cocrystals were transformed to 2:1 cocrystals upon slurrying in various solvents at 25 degrees C. The phase solubility diagram was used to define the stability regions of different solid phases in 2-propanol at 25 degrees C. While no phase stability region for 1:1 cocrystal could be found, the stable regions for the 2:1 cocrystals and their pure components were defined he eutectic points. The solubility of the 2:1 cocrystals was dependent on the concentration of the ligand in the solution and explained by the solubility product and 1:1 solution complexation. The mathematical models predicting the solubility of the 2:1 cocrystals were evaluated and found to fit the experimental data.
Place, publisher, year, edition, pages
American Chemical Society , 2010. Vol. 10, no 11, 4847-4855 p.
IdentifiersURN: urn:nbn:se:umu:diva-38561DOI: 10.1021/cg100823pISI: 000283631900027OAI: oai:DiVA.org:umu-38561DiVA: diva2:379637