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Monohydrous dihydrogen phosphate salts of norfloxacin and ciprofloxacin
2007 (English)In: Acta Crystallographica Section C: Crystal Structure Communications, ISSN 0108-2701, E-ISSN 1600-5759, Vol. 63, O731-O733 p.Article in journal (Refereed) Published
Abstract [en]

Norfloxacin and ciprofloxacin crystallize with phosphoric acid in aqueous solution to give the salts 4-(3-carboxy-1-ethyl-6-uoro- 4-oxo-1,4-dihydro-7-quinolyl) piperazinium dihydrogenphosphate monohydrate, C16H19FN3O3+center dot H2PO4-center dot H2O, and 4-(3-carboxy-1-cyclopropyl-6-uoro-4-oxo-1,4-dihydro-7quinolyl) piperazinium dihydrogenphosphate monohydrate, C17H19FN3O3+center dot H2PO4-center dot H2O, respectively. In the crystal structures, the phosphate anions and the piperazine rings of norfloxacin or ciprofloxacin form a 12-membered supramolecular synthon, viz. R-4(4)(12). The synthons R-4(4)(12) and R-2(2)(8) formed between adjacent phosphate anions result in the three-dimensional structures.

Place, publisher, year, edition, pages
2007. Vol. 63, O731-O733 p.
URN: urn:nbn:se:umu:diva-38599DOI: 10.1107/S0108270107053218ISI: 000251417400043OAI: diva2:379682
Available from: 2010-12-19 Created: 2010-12-19 Last updated: 2010-12-19

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