Change search
ReferencesLink to record
Permanent link

Direct link
Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology.
Show others and affiliations
2010 (English)In: PloS one, ISSN 1932-6203, Vol. 5, no 10, e13349- p.Article in journal (Refereed) Published
Abstract [en]

This is the first report characterizing local and systemic cytokine and chemokine responses in mice immunized with vaccines with different efficacies against aerosol challenge with virulent F. tularensis subsp. tularensis. It shows that increases in the levels of most of these immunomodulators, including those known to be critical for protective immunity, do not superficially correlate with protection unless adjusted for the effects of bacterial burden. Additionally, several cytokines were selectively suppressed in the lungs of naïve mice, suggesting that one mechanism of vaccine action is to overcome this pathogen-induced immunosuppression.

Place, publisher, year, edition, pages
2010. Vol. 5, no 10, e13349- p.
URN: urn:nbn:se:umu:diva-38653DOI: 10.1371/journal.pone.0013349ISI: 000282807300027PubMedID: 20967278OAI: diva2:379845
Available from: 2010-12-20 Created: 2010-12-20 Last updated: 2011-04-11Bibliographically approved

Open Access in DiVA

fulltext(3117 kB)130 downloads
File information
File name FULLTEXT01.pdfFile size 3117 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Sjöstedt, AndersRyden, Patrik
By organisation
Clinical BacteriologyDepartment of Mathematics and Mathematical Statistics

Search outside of DiVA

GoogleGoogle Scholar
Total: 130 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 52 hits
ReferencesLink to record
Permanent link

Direct link