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RNAs: regulators of bacterial virulence
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
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2010 (English)In: Nature Reviews Microbiology, ISSN 1740-1526, E-ISSN 1740-1534, Vol. 8, no 12, 857-866 p.Article in journal (Refereed) Published
Abstract [en]

RNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5' and 3' untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules that can influence protein expression and function in response to external cues such as temperature, pH and levels of metabolites. This Review discusses the mechanisms by which these regulatory RNAs, together with accessory proteins such as RNases, control the fate of mRNAs and proteins and how this regulation influences virulence in pathogenic bacteria.

Place, publisher, year, edition, pages
2010. Vol. 8, no 12, 857-866 p.
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Microbiology in the medical area
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Microbiology
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URN: urn:nbn:se:umu:diva-38680DOI: 10.1038/nrmicro2457ISI: 000284308200011PubMedID: 21079634OAI: oai:DiVA.org:umu-38680DiVA: diva2:380040
Available from: 2010-12-20 Created: 2010-12-20 Last updated: 2017-12-11Bibliographically approved

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Gripenland, JonasNetterling, SakuraLoh, EdmundTiensuu, TeresaJohansson, Jörgen

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