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RNA silencing in the antiviral innate immune defence--role of DEAD-box RNA helicases
Department of Pediatrics, University of Oulu, Oulu, Finland. (Institute of Medical Technology, University of Tampere, Tampere, Finland)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Institute of Medical Technology, University of Tampere, Tampere, Finland)
Institute of Medical Technology, University of Tampere, Tampere, Finland. (Department of Pediatrics, Tampere University Hospital, Tampere, Finland)
2010 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 71, no 3, 146-158 p.Article in journal (Refereed) Published
Abstract [en]

RNA silencing is an efficient biochemical tool for gene knock downs as well as physiological phenomenon playing a major role in diverse biological processes. Recent knowledge suggests that the same protein families which mediate the experimental RNA interference (RNAi) in the fruit fly Drosophila melanogaster cells also contribute to the antiviral host defence in both invertebrate model organisms and mammals. Additionally, another branch of RNA silencing, the microRNAs (miRNAs), has been recently described in the context of host defence. In several studies, miRNAs have been shown to regulate essential immune responses. This review summarizes basic concepts of RNAi and miRNAs, especially in the context of immune defence, focusing on the newly discovered role of DEAD-box helicases in the RNA interference and antiviral host defence.

Place, publisher, year, edition, pages
2010. Vol. 71, no 3, 146-158 p.
National Category
Microbiology in the medical area Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-38692DOI: 10.1111/j.1365-3083.2009.02362.xISI: 000274805900003PubMedID: 20415780OAI: oai:DiVA.org:umu-38692DiVA: diva2:380603
Available from: 2010-12-21 Created: 2010-12-21 Last updated: 2017-12-11Bibliographically approved

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CiteExportLink to record
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