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Testicular enlargement in a patient with a FSH-secreting pituitary adenoma
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
2010 (English)In: Endocrine (Basingstoke), ISSN 1355-008X, E-ISSN 1559-0100, Vol. 37, no 2, 289-293 p.Article in journal (Refereed) Published
Abstract [en]

Clinically non-functional pituitary adenomas are often derived from gonadotropin producing cells. However, gonadotropinomas causing elevated serum levels of follicle-stimulating hormone (FSH) and clinical signs of FSH hypersecretion are very rarely described. Our patient, a 56-year-old man, was referred to our clinic with signs of hypogonadism. Magnetic resonance imaging (MRI) and biochemical examinations showed a large pituitary adenoma and excessive levels of serum FSH. Clinical examination and ultrasound measurement revealed bilaterally enlarged testes. After pituitary surgery, serum FSH levels normalized and there was a decrease in testicular volume. This case suggests that supraphysiological levels of FSH from a gonadotropinoma can cause a clinically observable effect, i.e. testicular enlargement. This is in line with experimental studies showing biological effect of FSH from pituitary adenomas and previous occasional reports of ovarian hyperstimulation and testicular enlargement in patients with FSH-secreting gonadotropinomas.

Place, publisher, year, edition, pages
2010. Vol. 37, no 2, 289-293 p.
Keyword [en]
Pituitary adenoma, Follicle-stimulating hormone, Testis
National Category
Medical and Health Sciences
Research subject
Pathology
Identifiers
URN: urn:nbn:se:umu:diva-38722DOI: 10.1007/s12020-009-9302-zPubMedID: 20960265OAI: oai:DiVA.org:umu-38722DiVA: diva2:381073
Available from: 2010-12-23 Created: 2010-12-23 Last updated: 2017-12-11Bibliographically approved

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Dahlqvist, PerKoskinen, Lars-Owe DBrännström, ThomasHägg, Erik
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CiteExportLink to record
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