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Detection of the antiviral drug oseltamivir in aquatic environments
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2009 (English)In: PloS one, ISSN 1932-6203, Vol. 4, no 6, e6064- p.Article in journal (Refereed) Published
Abstract [en]

Oseltamivir (Tamiflu) is the most important antiviral drug available and a cornerstone in the defence against a future influenza pandemic. Recent publications have shown that the active metabolite, oseltamivir carboxylate (OC), is not degraded in sewage treatment plants and is also persistent in aquatic environments. This implies that OC will be present in aquatic environments in areas where oseltamivir is prescribed to patients for therapeutic use. The country where oseltamivir is used most is Japan, where it is used to treat seasonal flu. We measured the levels of OC in water samples from the Yodo River system in the Kyoto and Osaka prefectures, Japan, taken before and during the flu-season 2007/8. No OC was detected before the flu-season but 2-58 ng L(-1) was detected in the samples taken during the flu season. This study shows, for the first time, that low levels of oseltamivir can be found in the aquatic environment. Therefore the natural reservoir of influenza virus, dabbling ducks, is exposed to oseltamivir, which could promote the evolution of viral resistance.

Place, publisher, year, edition, pages
2009. Vol. 4, no 6, e6064- p.
URN: urn:nbn:se:umu:diva-38795DOI: 10.1371/journal.pone.0006064PubMedID: 19557131OAI: diva2:382643
Available from: 2011-01-03 Created: 2010-12-30 Last updated: 2011-01-05Bibliographically approved

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Söderström, HannaLindberg, Richard HFick, Jerker
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