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Clinical symptoms and HLA antigens in a family with reiters disease
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
Department of Internal Medicine, Division of Rheumatology, Danderyd University Hospital, Sweden.
Department of Rheumatology, Sahlgren University Hospital, Gothenburg, Sweden.
Department of Clinical Immunology, Huddinge University Hospital, Sweden.
1985 (English)In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, Vol. 14, no 2, 149-158 p.Article in journal (Refereed) Published
Abstract [en]

A clinical and immunogenetic study was performed on a three-generation family with Reiter's disease (RD). Twelve of 56 members of the family (33 clinically examined) including one in-law, had symptoms of arthritis, urethritis, conjunctivitis, uveitis, and/or mucocutaneous manifestations, but only one had the complete triad of Reiter's syndrome (RS). Radiographic sacro-iliitis was found in 7 individuals, and monoarticular onset was reported in 5 out of 7 with peripheral arthritis. HLA B27 was found in 26 of the 37 family members who were tissue typed (including one in-law). All individuals with RD were B27-positive. Seven different B27 phenotypes were identified. This finding suggests that RD is associated with the B27 antigen itself, and not to a gene closely linked to B27. From a pedigree analysis of this family an autosomal dominant inheritance with incomplete penetrance or multifactorial inheritance seemed the most probable alternatives. The family history is a useful adjunct in the diagnosis of RD.

Place, publisher, year, edition, pages
1985. Vol. 14, no 2, 149-158 p.
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:umu:diva-39215OAI: diva2:388721
Available from: 2011-01-18 Created: 2011-01-18 Last updated: 2011-01-20Bibliographically approved

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