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HLA haplotypes in a family with ankylosing-spondylitis and rheumatoid-arthritis
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
1985 (English)In: Journal of Rheumatology, ISSN 0315-162X, E-ISSN 1499-2752, Vol. 12, no 3, 518-522 p.Article in journal (Refereed) Published
Abstract [en]

HLA haplotypes (including A, B, C and DR loci) were studied in a family with members who had both rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Sacroiliitis was found in 7 family members, one of whom had AS and 2 others erosive, seropositive RA. They carried the B27-DR4 haplotype, suggesting a possible dual genetic association of the same haplotype in both RA and AS. Three other different HLA-B27 containing haplotype were found, 2 of which could be associated with sacroiliitis/AS. Within this family sacroiliitis and/or AS rather seemed associated with the B27 antigen itself than with the same haplotype.

Place, publisher, year, edition, pages
1985. Vol. 12, no 3, 518-522 p.
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:umu:diva-39208OAI: diva2:388760
Available from: 2011-01-18 Created: 2011-01-18 Last updated: 2011-01-20Bibliographically approved

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