Acetylator phenotypes in rheumatoid-arthritis patients with or without adverse drug-reactions to sodium-aurothiomalate or d-penicillamine
1987 (English)In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, Vol. 16, no 4, 235-239 p.Article in journal (Refereed) Published
The acetylator phenotype was determined in 59 patients with classical, seropositive and erosive rheumatoid arthritis (RA) treated with sodium-aurothiomalate or d-penicillamine. Patients with adverse drug reactions (ADR) leading to drug withdrawal (n=29) were compared with a group of patients without ADR (n=30). The frequency of slow acetylators was significantly (p< 0.05) increased in all RA patients, irrespective of the presence of ADR, particularly in the male patients, compared with a control population. No association was found between acetylator phenotype and clinical data or secondary Sjögrens's syndrome (SS).
Place, publisher, year, edition, pages
1987. Vol. 16, no 4, 235-239 p.
Acetylator phenotype, adverse drug reaction, sodium-aurothiomalate, penicillamine, RA
Rheumatology and Autoimmunity
IdentifiersURN: urn:nbn:se:umu:diva-39203DOI: 10.3109/03009748709102923OAI: oai:DiVA.org:umu-39203DiVA: diva2:388771