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Acetylator phenotypes in rheumatoid-arthritis patients with or without adverse drug-reactions to sodium-aurothiomalate or d-penicillamine
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
1987 (English)In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, E-ISSN 1502-7732, Vol. 16, no 4, 235-239 p.Article in journal (Refereed) Published
Abstract [en]

The acetylator phenotype was determined in 59 patients with classical, seropositive and erosive rheumatoid arthritis (RA) treated with sodium-aurothiomalate or d-penicillamine. Patients with adverse drug reactions (ADR) leading to drug withdrawal (n=29) were compared with a group of patients without ADR (n=30). The frequency of slow acetylators was significantly (p< 0.05) increased in all RA patients, irrespective of the presence of ADR, particularly in the male patients, compared with a control population. No association was found between acetylator phenotype and clinical data or secondary Sjögrens's syndrome (SS).

Place, publisher, year, edition, pages
1987. Vol. 16, no 4, 235-239 p.
Keyword [en]
Acetylator phenotype, adverse drug reaction, sodium-aurothiomalate, penicillamine, RA
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:umu:diva-39203DOI: 10.3109/03009748709102923OAI: oai:DiVA.org:umu-39203DiVA: diva2:388771
Available from: 2011-01-18 Created: 2011-01-18 Last updated: 2017-12-11Bibliographically approved

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