The effect of cph-82 on the growth of human-lymphocytes in vitro: definition of cytobiological action
1989 (English)In: British Journal of Rheumatology, ISSN 0263-7103, Vol. 28, no 5, 418-421 p.Article in journal (Refereed) Published
A drug composed of two semisynthetic podophyltine derivatives, CPH 82, has recently been launched for the treatment of severe rheumatoid arthritis. The present in vitro study of PHA-stimulated human T-lymphocytes showed that CPH 82 arrested cell division in a metaphase-like configuration. The cell cycle effects of CPH 82 were indistinguishable from the cell cycle effects of the classical microtubule depolymerizers, Colcemid (a colchicine derivative) and podophyllotoxin. A CPH 82 concentration of 1 (µg/ml, which is close to therapeutic serum concentrations, had an almost maximal effect on cell division. It is suggested that at least part of the anti-inflammatory effect of CPH 82 is due to a colchicine-like activity on, for example, proliferating lymphocytes.
Place, publisher, year, edition, pages
1989. Vol. 28, no 5, 418-421 p.
Podophylline derivative, CPH 82, Antimitotic effects, Arrest
Rheumatology and Autoimmunity
IdentifiersURN: urn:nbn:se:umu:diva-39198DOI: 10.1093/rheumatology/28.5.418OAI: oai:DiVA.org:umu-39198DiVA: diva2:388786