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The effect of cph-82 on the growth of human-lymphocytes in vitro: definition of cytobiological action
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
Blood Centre, University Hospital S-901 85 Umeå, Sweden.
Blood Centre, University Hospital S-901 85 Umeå, Sweden.
Department of Clinical Genetics, University Hospital S-901 85 Umeå, Sweden.
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1989 (English)In: British Journal of Rheumatology, ISSN 0263-7103, Vol. 28, no 5, 418-421 p.Article in journal (Refereed) Published
Abstract [en]

A drug composed of two semisynthetic podophyltine derivatives, CPH 82, has recently been launched for the treatment of severe rheumatoid arthritis. The present in vitro study of PHA-stimulated human T-lymphocytes showed that CPH 82 arrested cell division in a metaphase-like configuration. The cell cycle effects of CPH 82 were indistinguishable from the cell cycle effects of the classical microtubule depolymerizers, Colcemid (a colchicine derivative) and podophyllotoxin. A CPH 82 concentration of 1 (µg/ml, which is close to therapeutic serum concentrations, had an almost maximal effect on cell division. It is suggested that at least part of the anti-inflammatory effect of CPH 82 is due to a colchicine-like activity on, for example, proliferating lymphocytes.

Place, publisher, year, edition, pages
1989. Vol. 28, no 5, 418-421 p.
Keyword [en]
Podophylline derivative, CPH 82, Antimitotic effects, Arrest
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:umu:diva-39198DOI: 10.1093/rheumatology/28.5.418OAI: diva2:388786
Available from: 2011-01-18 Created: 2011-01-18 Last updated: 2011-01-20Bibliographically approved

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