Peripheral-blood lymphocyte subsets in polymyalgia-rheumatica
1995 (English)In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 14, 62-67 p.Article in journal (Refereed) Published
Peripheral blood lymphocytes from 23 patients with polymyalgia rheumatica (PMR) were characterized using monoclonal antibodies and flow cytometry in a two-year prospective study. There were no significant differences in absolute numbers or relative percentages of lymphocytes or CD3+, CD4+, CD8+ T cells or the CD4+ T cell functional subsets, virgin (CD4+ CD45RA+) and memory (CD4+ CD29+) T cells, in patients before or during corticosteroid treatment compared to controls. Previous reports on decreased levels of CD8+ T cells as a characteristic of PMR/giant cell arteritis was not confirmed. The absolute number and relative percentage of lymphocytes with natural killer cell activity, CD16+ CD56+ cells, were significantly lower in patients with active untreated PMR as well as during corticosteriod treatment compared to controls, but at the two-year follow-up the difference was less marked.
Place, publisher, year, edition, pages
1995. Vol. 14, 62-67 p.
POLYMYALGIA RHEUMATICA; T LYMPHOCYTE SUBSETS; NATURAL KILLER CELLS; HLA-DR; FLOW CYTOMETRY
IdentifiersURN: urn:nbn:se:umu:diva-39191OAI: oai:DiVA.org:umu-39191DiVA: diva2:388806