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Chromosomal changes in rheumatoid arthritis patients treated with CPH82
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
1996 (English)In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 15, no 6, 584-589 p.Article in journal (Refereed) Published
Abstract [en]

Chromosomal changes were assessed in 19 patients with rheumatoid arthritis (RA) treated with CPH82, a benzylidated podophyllotoxin glycoside, for up to one ve:lr. The frequency of chromosomal aberrations (CA) and sister chromatid exchanges (SCE) in peripheral lymphocytes increased significantly after 12 weeks of treatment and remained elevated after 48 weeks treatment in peripheral lymphocytes. The number of CA and SCE were significantly increased in CPH82 treated patients compared with the RA patients treated with other disease modifying anti-rheumatic drugs (sulphasalazine, gold, D-penicillamine, azathioprine, methotrexate, cyclophosphamide). Only two patients treated with cyclophosphamide and azathioprine had changes of comparable levels, The results of this study suggest a mutagenic potential of CPH82 similar to that described for other immunosuppressive drugs and the newer podophyllotoxin derivatives, etoposide and teniposide.

Place, publisher, year, edition, pages
1996. Vol. 15, no 6, 584-589 p.
Keyword [en]
CPH82; podophyllatoxin derivative; chromosomal aberration; sister chromatid exchange; mutagenic
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:umu:diva-39190DOI: 10.1007/BF02238548OAI: diva2:388807
Available from: 2011-01-18 Created: 2011-01-18 Last updated: 2011-01-20Bibliographically approved

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