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Cytokines and adhesion molecules in patients with polymyalgia rheumatica
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
1998 (English)In: British Journal of Rheumatology, ISSN 0263-7103, Vol. 37, no 7, 766-769 p.Article in journal (Refereed) Published
Abstract [en]

Serum levels of interleukin-1 beta (IL-1 beta), IL-1 receptor antagonist (IL-1ra), tumour necrosis factor alpha (TNF-alpha), IL-6, soluble IL-6 receptor (sIL-6R), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin were measured in 15 patients with newly diagnosed polymyalgia rheumatica (PMR) before and after 3 months of corticosteroid therapy. Both IL-6 and IL-1ra were significantly increased in untreated PMR and remained elevated compared with controls during therapy, although significantly only for sIL-1ra. sICAM-1 was raised in 12/15 (87%) patients at diagnosis and remained high in 10/14 (71%) patients; soluble E-selectin levels were initially raised in 6/15 (40%) patients and decreased with therapy in those with the highest levels. IL-6, IL-1ra and sICAM-1 are sensitive indicators of continuing immunological activation in PMR; the advantages of these markers in assessing the response to therapy should be investigated in a longitudinal study.

Place, publisher, year, edition, pages
1998. Vol. 37, no 7, 766-769 p.
Keyword [en]
polymyalgia rheumatica; IL-1 beta; IL-1ra; IL-6; sIL-6R; TNF-alpha; sICAM-1; sE-selectin
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:umu:diva-39186DOI: 10.1093/rheumatology/37.7.766OAI: diva2:388821
Available from: 2011-01-18 Created: 2011-01-18 Last updated: 2011-01-21Bibliographically approved

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