Increase in bombesin-like peptides in the spinal cord after dexamethasone treatment of adrenalectomized rats
1999 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 275, no 3, 179-182 p.Article in journal (Refereed) Published
The potential influence of corticosteroids on the bombesin (BN)-like peptide family is unknown. Therefore, the effects of adrenalectomy (ADX) on the nervous system of Sprague-Dawley rats, some of them being treated with high doses of the synthetic glucocorticoid dexamethasone (DEX), were investigated. After 8-10 days of treatment, the rats were sacrificed and tissues were prepared for radioimmunoassay (RIA) and immunohistochemical examination. We found an increase in BN-like immunoreactivity in the superficial layers of the dorsal horn of the lumbar spinal cord in the ADX + DEX animals. This increase was confirmed by RIA (P < 0.05). The observations show that the expression of BN-like peptides is influenced by glucocorticoids. The altered levels of BN-like peptides may be related to the trophic and antinociceptive effects previously reported for these peptides. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Place, publisher, year, edition, pages
1999. Vol. 275, no 3, 179-182 p.
rat; adrenalectomy; dexamethasone; glucocorticoids; steroids; bombesin; neuropeptides
Rheumatology and Autoimmunity
IdentifiersURN: urn:nbn:se:umu:diva-39181DOI: 10.1016/S0304-3940(99)00772-7OAI: oai:DiVA.org:umu-39181DiVA: diva2:388828