Change search
ReferencesLink to record
Permanent link

Direct link
Increased levels of autoantibodies against copper-oxidized low density lipoprotein, malondialdehyde-modified low density lipoprotein and cardiolipin in patients with rheumatoid arthritis
Show others and affiliations
2002 (English)In: Rhematology Int, ISSN 1462-0324, E-ISSN 1462-0332, Vol. 41, 988-995 p.Article in journal (Refereed) Published
Abstract [en]

Objectives. To analyse the association of autoantibodies against cardiolipin (CL) and oxidized low density lipoproteins [copper-oxidized low density lipoprotein (oxLDL), malondialdehyde-modified LDL (MDA-LDL)] with rheumatoid arthritis (RA) and cardiovascular complications. Methods. One hundred and twenty-one patients with RA were consecutively included. Autoantibodies were determined by ELISA. Healthy individuals from the same region were used as controls. Results. Levels of IgG, IgM and IgA antibodies against MDA-LDL and CL, as well as IgG and IgA antibodies against oxLDL were increased in the patients (P<0.01). The prevalence of IgG, IgM and IgA antibodies against CL was higher than in the normal population (74, 82 and 14%, respectively). The prevalence of IgG and IgA antibodies against oxLDL was also significantly increased (35 and 25%, respectively) and so was the prevalence of IgG and IgM antibodies against MDA-LDL (17 and 26%, respectively) compared with controls. The levels of IgM and IgA antibodies against aCL and IgM against MDA-LDL were increased in patients with extra-articular manifestations. Patients who developed myocardial infarction had a higher prevalence of IgG antibodies against MDA-LDL (P=0.04). There were substantial correlations between the levels of antibodies against oxLDL, MDA-LDL and CL. Conclusions. RA patients had increased levels and prevalence of autoantibodies against CL, oxLDL and MDA-LDL, with associations to severity of disease and cardiovascular complications.

Place, publisher, year, edition, pages
2002. Vol. 41, 988-995 p.
Keyword [en]
autoantibody; rheumatoid arthritis; cardiolipin; oxLDL; MDA-LDL; cardiovascular disease
URN: urn:nbn:se:umu:diva-39161OAI: diva2:388924
Available from: 2011-01-18 Created: 2011-01-18 Last updated: 2011-01-18

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Rantapää-Dahlqvist, Solbritt
In the same journal
Rhematology Int

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 16 hits
ReferencesLink to record
Permanent link

Direct link