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Oral lichen planus and the p53 family: what do we know?
Umeå University, Faculty of Medicine, Department of Odontology, Endodontics.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
2011 (English)In: Journal of Oral Pathology & Medicine, ISSN 0904-2512, E-ISSN 1600-0714, Vol. 40, no 4, 281-285 p.Article in journal (Refereed) Published
Abstract [en]

J Oral Pathol Med (2010) Oral lichen planus (OLP) is a relatively common chronic disease of the oral mucosa for which the aetiopathogenesis is not fully understood. It mainly affects middle aged and elderly. The finding of autoantibodies against p63, a member of the p53 family, is a strong indication of autoimmunity as a causative or contributing factor. The WHO classified OLP as a potentially malignant disorder, but still there is an ongoing debate in the literature on this subject. The TP53 gene encodes a tumour suppressor protein that is involved in induction of cell-cycle arrest or apoptosis of DNA-damaged cells. The p63 gene encodes six different proteins that are crucial for formation of the oral mucosa and skin. The coordinated stabilization of p53 and decreased expression of p63 seen in OLP cause induction of apoptosis enabling removal of DNA-damaged cells. In view of the complexity of cancerogenesis, no firm statement can at present be made about the relevance of the observed relationship between p53 and p63 and the possible malignant transformation of OLP.

Place, publisher, year, edition, pages
2011. Vol. 40, no 4, 281-285 p.
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URN: urn:nbn:se:umu:diva-39296DOI: 10.1111/j.1600-0714.2010.00979.xPubMedID: 21138483OAI: diva2:390354
Available from: 2011-01-21 Created: 2011-01-21 Last updated: 2011-12-01Bibliographically approved

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Publisher's full textPubMedRättelse: Letter to the editor: Reply to H. M. Ögmundsdóttir & W. P. Holbrook by M. Ebrahimi et al.

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