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Proinsulin/C-peptide ratio, glucagon and remission in new-onset type 1 diabetes mellitus in young adults
Institute of Medical Sciences, Uppsala University, Uppsala.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.ORCID iD: 0000-0002-5095-3454
Department of Clinical and Experimental Medicine, Linköping University, Linköping.
Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
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2011 (English)In: Diabetic Medicine, ISSN 0742-3071, E-ISSN 1464-5491, Vol. 28, no 2, 156-161 p.Article in journal (Refereed) Published
Abstract [en]

Aims After initiation of treatment in Type 1 diabetes, a period with lower insulin requirement often follows, reflecting increased insulin sensitivity and improved insulin secretion. We explored if efficiency of proinsulin processing is associated with the remission phenomenon.

Methods Seventy-eight patients with new-onset Type 1 diabetes were followed prospectively for 3 years. Daily insulin dosage, HbA(1c) , plasma glucose, proinsulin, C-peptide, glucagon concentrations and islet antibodies were determined at diagnosis and after 3, 6, 9, 12, 18, 24, 30 and 36 months. We studied remission, defined as an insulin dose ≤ 0.3 U kg(-1)  24 h(-1) and HbA(1c) within the normal range, in relation to the above-mentioned variables.

Results A rise and subsequent decline in plasma proinsulin and C-peptide concentrations was observed. Forty-five per cent of the patients experienced remission at one or more times, characterized by higher proinsulin and C-peptide levels, and lower proinsulin/C-peptide ratios, indicating more efficient proinsulin processing, compared with those not in remission. Non-remission also tended to be associated with higher glucagon values. Patients entering remission were more often men, had higher BMI at diagnosis, but did not differ at baseline with respect to islet antibody titres compared with patients with no remission.

Conclusions Remissions after diagnosis of Type 1 diabetes were associated with lower proinsulin/C-peptide ratios, suggesting more efficient proinsulin processing, and tended to have lower glucagon release than non-remissions. This indicates that, in remission, the residual islets maintain a secretion of insulin and glucagon of benefit for control of hepatic glucose production.

Place, publisher, year, edition, pages
2011. Vol. 28, no 2, 156-161 p.
Keyword [en]
C-peptide; glucagon; proinsulin; remission; Type 1 diabetes
URN: urn:nbn:se:umu:diva-39338DOI: 10.1111/j.1464-5491.2010.03191.xPubMedID: 21219422OAI: diva2:390898
Available from: 2011-01-24 Created: 2011-01-24 Last updated: 2015-04-29Bibliographically approved

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