Growth factor PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan
2010 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 5, no 12, e14393- p.Article in journal (Refereed) Published
Co-cultivation of cardiomyocytes and fibroblasts (80%/20%) increased HA concentration far more that can be explained by HA synthesis by the two cell types separately, revealing a crosstalk between cardiomyocytes and fibroblasts that induces HA synthesis. We conclude that dynamic changes of the myocardium, such as in cardiac hypertrophy, do not depend on the cardiomyocyte alone, but are achieved when both cardiomyocytes and fibroblasts are present.
Place, publisher, year, edition, pages
2010. Vol. 5, no 12, e14393- p.
IdentifiersURN: urn:nbn:se:umu:diva-39573DOI: 10.1371/journal.pone.0014393ISI: 000285576900008PubMedID: 21200430OAI: oai:DiVA.org:umu-39573DiVA: diva2:393912