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Fractionated irradiation and early changes in noradrenaline induced potassium efflux(86Rb+) in rat parotid gland
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
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1992 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 31, no 3, 359-364 p.Article in journal (Refereed) Published
Abstract [en]

The effects of fractionated irradiation on the electrolyte fluid secretion from rat parotid gland were studied. Secretion was measured as noradrenaline stimulated potassium efflux in vitro with Rb-86+ as tracer for potassium. The irradiation was delivered either as a five-day schedule (total dose 20, 25, 30, 35, 40, 45 Gy) or a two-day schedule (total dose 24, 32 Gy). The noradrenaline stimulated efflux was decreased in comparison with contralateral controls 10 days after the last irradiation. The effect was dose-dependent. Based on the data available, alpha/beta ratio of the used system was calculated to about 20 Gy, which corresponds to other results regarding early radiation effects.

Place, publisher, year, edition, pages
1992. Vol. 31, no 3, 359-364 p.
Identifiers
URN: urn:nbn:se:umu:diva-39968ISI: A1992JD34100014OAI: oai:DiVA.org:umu-39968DiVA: diva2:396935
Available from: 2011-02-11 Created: 2011-02-11 Last updated: 2017-12-11Bibliographically approved

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Franzén, LarsKarlsson, MikaelLittbrand, Bo

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