Fractionated irradiation and early changes in noradrenaline induced potassium efflux(86Rb+) in rat parotid gland
1992 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 31, no 3, 359-364 p.Article in journal (Refereed) Published
The effects of fractionated irradiation on the electrolyte fluid secretion from rat parotid gland were studied. Secretion was measured as noradrenaline stimulated potassium efflux in vitro with Rb-86+ as tracer for potassium. The irradiation was delivered either as a five-day schedule (total dose 20, 25, 30, 35, 40, 45 Gy) or a two-day schedule (total dose 24, 32 Gy). The noradrenaline stimulated efflux was decreased in comparison with contralateral controls 10 days after the last irradiation. The effect was dose-dependent. Based on the data available, alpha/beta ratio of the used system was calculated to about 20 Gy, which corresponds to other results regarding early radiation effects.
Place, publisher, year, edition, pages
1992. Vol. 31, no 3, 359-364 p.
IdentifiersURN: urn:nbn:se:umu:diva-39968ISI: A1992JD34100014OAI: oai:DiVA.org:umu-39968DiVA: diva2:396935