Structure of the C-terminal domain of the surface antigen SpaP from the caries pathogen Streptococcus mutans
2011 (English)In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, ISSN 1744-3091, E-ISSN 1744-3091, Vol. 67, 23-26 p.Article in journal (Refereed) Published
SpaP is a 1500-residue adhesin expressed on the surface of the caries-implicated bacterium Streptococcus mutans. SpaP is a member of the antigen I/II (AgI/II) family of proteins expressed by oral streptococci. These surface proteins are crucial for the incorporation of streptococci into dental plaque. The structure of the C-terminal domain of SpaP (residues 1136-1489) was solved and refined to 2.2 Å resolution with six molecules in the asymmetric unit. Similar to a related AgI/II structure, SpaP is stabilized by isopeptide bonds between lysine and asparagine side chains.
Place, publisher, year, edition, pages
International Union of Crystallography , 2011. Vol. 67, 23-26 p.
adhesin, caries, protein crystallography
Biochemistry and Molecular Biology Dentistry
Research subject Molecular Biology; Infectious Diseases; Odontology
IdentifiersURN: urn:nbn:se:umu:diva-40180DOI: 10.1107/S174430911004443XOAI: oai:DiVA.org:umu-40180DiVA: diva2:398145
FunderSwedish Research Council