umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Structure of the sortase AcSrtC-1 from Actinomyces oris
Umeå University, Faculty of Medicine, Department of Odontology. (Karina Persson)
2011 (English)In: Acta Crystallographica Section D: Biological Crystallography, ISSN 0907-4449, E-ISSN 1399-0047, Vol. 67, 212-217 p.Article in journal (Refereed) Published
Abstract [en]

The crystal structure of the sortase AcSrtC-1 from the oral microorganism Actinomyces oris has been determined to 2.4 Å resolution. AcSrtC-1 is a cysteine transpeptidase that is responsible for the formation of fimbriae by the polymerization of a shaft protein. Similar to other pili-associated sortases, the AcSrtC-1 active site is protected by a flexible lid. The asymmetric unit contains five AcSrtC-1 molecules and their catalytic Cys-His-Arg triads are trapped in two different conformations. It is also shown that the thermostability of the enzyme is increased by the presence of calcium.

Place, publisher, year, edition, pages
International Union of Crystallography , 2011. Vol. 67, 212-217 p.
Keyword [en]
sortase, oral biofilm, fimbriae
National Category
Dentistry Dentistry Microbiology in the medical area
Research subject
Molecular Biology; Odontology
Identifiers
URN: urn:nbn:se:umu:diva-40184DOI: 10.1107/S0907444911004215OAI: oai:DiVA.org:umu-40184DiVA: diva2:398150
Funder
Swedish Research Council
Available from: 2011-02-18 Created: 2011-02-16 Last updated: 2017-12-11Bibliographically approved

Open Access in DiVA

fulltext(747 kB)354 downloads
File information
File name FULLTEXT01.pdfFile size 747 kBChecksum SHA-512
401194302e2bea582a40531e2e4c9215c7bb597edd4182c09cba1739cd53450612ea56ae90eedde7021306be9fdb7e31c6c42a329cd29b5edf1949d956a93918
Type fulltextMimetype application/pdf

Other links

Publisher's full texthttp://journals.iucr.org/d/issues/2011/03/00/hm5095/index.html

Search in DiVA

By author/editor
Persson, Karina
By organisation
Department of Odontology
In the same journal
Acta Crystallographica Section D: Biological Crystallography
DentistryDentistryMicrobiology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
Total: 354 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 123 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf