Structural basis of signal-sequence recognition by the signal recognition particle
2011 (English)In: Nature Structural & Molecular Biology, ISSN 1545-9993, E-ISSN 1545-9985, Vol. 18, no 3, 389-391 p.Article in journal (Refereed) Published
The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-Å structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180° flip of the NG domain—structural changes that ensure a hierarchical succession of events during protein targeting.
Place, publisher, year, edition, pages
2011. Vol. 18, no 3, 389-391 p.
IdentifiersURN: urn:nbn:se:umu:diva-40342DOI: 10.1038/nsmb.1994OAI: oai:DiVA.org:umu-40342DiVA: diva2:399363
Published online 20 February 20112011-02-222011-02-222011-03-11Bibliographically approved