Diagnostic properties of metabolic perturbations in rheumatoid arthritis
2011 (English)In: Arthritis Research & Therapy, ISSN 1478-6362, Vol. 13, no 1, R19- p.Article in journal (Refereed) Published
INTRODUCTION: The aim of the study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. METHODS: We compared the metabolic profile of patients with RA with those of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. RESULTS: RA patients were diagnosed with a sensitivity of 93 % and a specificity of 70 % in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90 % and a specificity of 94 %. Glyceric acid, D-ribofuranoise and hypoxanthine were increased in RA patients, whereas histidine, threonic acid, methionine, cholesterol, asparagine and threonine were all decreased when compared with healthy controls. CONCLUSIONS: Metabolite profiling (metabolomics) is a potentially useful technique for diagnosing RA. The predictive value was irrespective of the presence of antibodies against cyclic citrullinated peptides (ACPA).
Place, publisher, year, edition, pages
2011. Vol. 13, no 1, R19- p.
Rheumatology and Autoimmunity Medicinal Chemistry
Research subject Medicine
IdentifiersURN: urn:nbn:se:umu:diva-40411DOI: 10.1186/ar3243PubMedID: 21303541OAI: oai:DiVA.org:umu-40411DiVA: diva2:399596