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Stimulation of IL-6 cytokines in fibroblasts by toll-like receptors 2
University of Sao Paulo.
Umeå University, Faculty of Medicine, Department of Odontology, Oral Cell Biology.
Umeå University, Faculty of Medicine, Department of Odontology, Oral Cell Biology.
Umeå University, Faculty of Medicine, Department of Odontology, Oral Cell Biology.
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2010 (English)In: Journal of Dental Research, ISSN 0022-0345, E-ISSN 1544-0591, Vol. 89, no 8, 802-807 p.Article in journal (Refereed) Published
Abstract [en]

The osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and tumor necrosis factor-alpha (TNF-alpha). In the present study, we investigated whether signaling through Toll-like receptor 2 (TLR2) can affect the expression of these cytokines in human gingival fibroblasts. Lipopolysac-charide (LPS) from P. gingivalis was found to stimulate IL-6 and LIF mRNA and protein, but not IL-11 or OSM mRNA. Using two synthetic ligands acting specifically at TLR2 and siRNA knockdown of TLR2, we demonstrated the important role of TLR2 in the stimulation of IL-6 and LIF in gingival fibroblasts. Analysis of these data suggests that signaling through the innate immune system controls the expression of osteotropic cytokines in human gingival fibroblasts.

Place, publisher, year, edition, pages
2010. Vol. 89, no 8, 802-807 p.
Keyword [en]
gingival fibroblasts, IL-6, LIF, IL-11, TLR
National Category
Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-40518DOI: 10.1177/0022034510366898ISI: 000280194800008PubMedID: 20505053OAI: oai:DiVA.org:umu-40518DiVA: diva2:400290
Available from: 2011-02-25 Created: 2011-02-25 Last updated: 2017-12-11Bibliographically approved

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Palmqvist, PyLundgren, IngerLie, AnitaLundberg, PernillaLerner, Ulf H
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CiteExportLink to record
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