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Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase-1 mutant mouse in vivo: evidence for increased persistent inward currents
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2010 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 200, no 4, 361-376 p.Article in journal (Refereed) Published
Abstract [en]

We demonstrated that, in vivo, at resting membrane potential, spinal motor neurones of the adult G127X mice do not show an increased excitability. However, when depolarized they show evidence of an increased PIC and less SFA which may contribute to excitotoxicity of these neurones as the disease progresses.

Place, publisher, year, edition, pages
2010. Vol. 200, no 4, 361-376 p.
Keyword [en]
amyotrophic lateral sclerosis;G 127X;intrinsic properties;mice;motor neurones;SOD1
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:umu:diva-40742DOI: 10.1111/j.1748-1716.2010.02188.xISI: 000284810500007PubMedID: 20874803OAI: oai:DiVA.org:umu-40742DiVA: diva2:402378
Available from: 2011-03-08 Created: 2011-03-08 Last updated: 2017-12-11Bibliographically approved

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