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Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2010 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 70, no 13, 1461-1470 p.Article in journal (Refereed) Published
Abstract [en]

Our results argue for a role for IDO mediated immune suppression in the early stages of prostate cancer progression. However, since the intra-tumor IDO expression in J(-/-) mice was indistinguishable from that of C57BL/6 animals the IDO expression in the tumor tissue appears to be irrelevant for TRAMP tumor incidence.

Place, publisher, year, edition, pages
2010. Vol. 70, no 13, 1461-1470 p.
Keyword [en]
TRAMP;IDO;immunology
National Category
Pathobiology
Research subject
Pathology
Identifiers
URN: urn:nbn:se:umu:diva-40760DOI: 10.1002/pros.21181ISI: 000281542100010PubMedID: 20687219OAI: oai:DiVA.org:umu-40760DiVA: diva2:402669
Available from: 2011-03-09 Created: 2011-03-09 Last updated: 2017-12-11Bibliographically approved

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