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Fish oil delays lymphoma progression in the TLL mouse
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
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2010 (English)In: Leukemia and Lymphoma, ISSN 1042-8194, E-ISSN 1029-2403, Vol. 51, no 11, 2092-2097 p.Article in journal (Refereed) Published
Abstract [en]

The objective was to investigate the effects of omega-3 fatty acids, known for their anti-inflammatory effects, on time to lymphoma progression and survival in the TLL mouse, a strain genetically prone to developing aggressive T-cell lymphoma. Compared to mice fed a standard diet, TLL mice fed omega-3 (menhaden fish oil) experienced a significant delay in disease progression and were more likely to remain alive and symptom free during the first 8 months of the study. In contrast, omega-6 supplementation (corn oil) did not significantly affect lymphoma progression. Irrespective of diet, all mice eventually progressed, and 1-year survival was not different between the groups. Immunological analysis demonstrated a significantly altered B-cell compartment and fewer NK cells in healthy C57Black6 mice fed omega-3, compared to controls. In conclusion, a diet rich in omega-3 fatty acids delays lymphoma development in the TLL mouse possibly by mechanisms that include complex effects on immune function.

Place, publisher, year, edition, pages
2010. Vol. 51, no 11, 2092-2097 p.
Keyword [en]
T-cell lymphoma, mouse, fish oil, omega-3, immunity
National Category
Cancer and Oncology
Research subject
Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-40766DOI: 10.3109/10428194.2010.522284ISI: 000284219400019PubMedID: 20919854OAI: oai:DiVA.org:umu-40766DiVA: diva2:402690
Available from: 2011-03-09 Created: 2011-03-09 Last updated: 2017-12-11Bibliographically approved

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Norén-Nyström, UlrikaLarefalk, ÅsaHolmberg, Dan

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