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The TAK1-TRAF6 signalling pathway
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
2010 (English)In: International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, E-ISSN 1878-5875, Vol. 42, no 5, 585-589 p.Article in journal (Refereed) Published
Abstract [en]

Cellular responses to pathogens, growth factors, cytokines, extra- or intra-cellular stress, is a prerequisite for the cell to adapt to novel and potentially dangerous situations. If the changes in the extra- or intra-cellular milieu causes DNA-damage or revoke a signalling pathway utilized during morphogenesis, the epithelial cells might be forced to undergo programmed cell death (apoptosis) in the benefit for the whole organism or transform to a mesenchymal cell type (epithelial to mesenchymal transition; EMT), in respond to a specific stimuli. An overview is presented over the current knowledge for the key components in signal transduction in homeostasis, inflammation and cancer. A handful of transcription factors are crucial for the determination of the specific cellular responses, where the transforming growth factor-beta (TGF-beta) is an important factor as discussed in this review.

Place, publisher, year, edition, pages
2010. Vol. 42, no 5, 585-589 p.
Keyword [en]
Inflammation; Kinase activation; Transforming growth factor-β; Ubiquitination
National Category
Medical and Health Sciences
Research subject
URN: urn:nbn:se:umu:diva-40795DOI: 10.1016/j.biocel.2009.12.023PubMedID: 20060931OAI: diva2:402772
Available from: 2011-03-09 Created: 2011-03-09 Last updated: 2011-12-14Bibliographically approved

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