Triglyceride lipases and atherosclerosis
2010 (English)In: Current Opinion in Lipidology, ISSN 0957-9672, E-ISSN 1473-6535, Vol. 21, no 5, 409-415 p.Article in journal (Refereed) Published
There are several ways by which derangement of the lipases may contribute to atherogenesis. Lipase actions are major determinants of plasma lipoprotein patterns. LPL activity must be modulated in relation to the physiological situation (feeding, fasting, exercise, etc.). Fatty acids and monoglycerides generated must be efficiently removed so that they do not endanger the integrity of the endothelium, cause lipotoxic reactions or both. In addition, the lipases may cause binding and endocytosis of lipoprotein particles in the artery wall.
Place, publisher, year, edition, pages
2010. Vol. 21, no 5, 409-415 p.
endothelial lipase, endothelial lipolysis site, hepatic lipase, lipoprotein lipase
Medical and Health Sciences
Research subject Physical Chemistry
IdentifiersURN: urn:nbn:se:umu:diva-40812DOI: 10.1097/MOL.0b013e32833ded83ISI: 000281619300003PubMedID: 20683326OAI: oai:DiVA.org:umu-40812DiVA: diva2:402976