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Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk
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2010 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 59, no 3, 741-746 p.Article in journal (Refereed) Published
Abstract [en]

We identified six highly correlated SNPs that show strong and comparable associations with risk of type 2 diabetes, but further refinement of these associations will require large sample sizes (>100,000) or studies in ethnically diverse populations. Low frequency variants in WFS1 are unlikely to have a large impact on type 2 diabetes risk in white U.K. populations, highlighting the complexities of undertaking association studies with low-frequency variants identified by resequencing.

Place, publisher, year, edition, pages
2010. Vol. 59, no 3, 741-746 p.
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URN: urn:nbn:se:umu:diva-40903DOI: 10.2337/db09-0920PubMedID: 20028947OAI: oai:DiVA.org:umu-40903DiVA: diva2:403517
Available from: 2011-03-14 Created: 2011-03-14 Last updated: 2017-12-11Bibliographically approved

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