Change search
ReferencesLink to record
Permanent link

Direct link
Clinical course and outcome of schizophrenia in a predominantly treatment-naive cohort in rural Ethiopia
Addis Ababa University, Ethiopia.
WHO Regional Office for Africa, Brazzaville, Congo .
King's College London, United Kingdom.
Addis Ababa University, Ethiopia.
Show others and affiliations
2009 (English)In: Schizophrenia Bulletin, ISSN 0586-7614, E-ISSN 1745-1701, Vol. 35, no 3, 646-654 p.Article in journal (Refereed) Published
Abstract [en]

The established view that schizophrenia may have a favorable outcome in developing countries has been recently challenged; however, systematic studies are scarce. In this report, we describe the clinical outcome of schizophrenia among a predominantly treatment-naive cohort in a rural community setting in Ethiopia. The cohort was identified in a 2-stage sampling design using key informants and measurement-based assessment. Follow-up assessments were conducted monthly for a mean duration of 3.4 years (range 1-6 years). After screening 68 378 adults, ages 15-49 years, 321 cases with schizophrenia (82.7% men and 89.6% treatment naive) were identified. During follow-up, about a third (30.8%) of cases were continuously ill while most of the remaining cohort experienced an episodic course. Only 5.7% of the cases enjoyed a near-continuous complete remission. In the final year of follow-up, over half of the cases (54%) were in psychotic episode, while 17.6% were in partial remission and 27.4% were in complete remission for at least the month preceding the follow-up assessment. Living in a household with 3 or more adults, later age of onset, and taking antipsychotic medication for at least 50% of the follow-up period predicted complete remission. Although outcome in this setting appears better than in developed countries, the very low proportion of participants in complete remission supports the recent observation that the outcome of schizophrenia in developing countries may be heterogeneous rather than uniformly favorable. Improving access to treatment may be the logical next step to improve outcome of schizophrenia in this setting.

Place, publisher, year, edition, pages
2009. Vol. 35, no 3, 646-654 p.
URN: urn:nbn:se:umu:diva-40937DOI: 10.1093/schbul/sbn029PubMedID: 18448478OAI: diva2:403868
Available from: 2011-03-15 Created: 2011-03-15 Last updated: 2012-01-26Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kullgren, Gunnar
By organisation
In the same journal
Schizophrenia Bulletin

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 73 hits
ReferencesLink to record
Permanent link

Direct link