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Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.ORCID iD: 0000-0002-8114-7615
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2010 (English)In: Progress in Neuro-psychopharmacology and Biological Psychiatry, ISSN 0278-5846, E-ISSN 1878-4216, Vol. 34, no 6, 1094-1097 p.Article in journal (Refereed) Published
Abstract [en]

The early development of dopaminergic pathways has been attributed importance for the aetiology of schizophrenia. Several transcription factors are involved in the survival and maturation of dopamine neurons, including LMX1A, LMX1B and PITX3. The possibility that polymorphisms in these genes may influence the development and/or the maintenance of dopaminergic neurons prompted us to investigate if five single nucleotide polymorphisms (SNPs) previously linked to Parkinson's disease are associated with this disorder. Preliminary evidence that genetic variation in LMX1A (rs6668493, rs4657411), LMX1B (rs10987386) and PITX3 (rs4919621) may increase the risk of developing schizophrenia is presented.

Place, publisher, year, edition, pages
2010. Vol. 34, no 6, 1094-1097 p.
Keyword [en]
LMX1A; LMX1B; Neurodevelopment; PITX3; Schizophrenia, catechol-o-methyltransferase; prospective cohort; neurons; gene; transporter; expression; cells; psychosis; variants; genotype
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URN: urn:nbn:se:umu:diva-40998DOI: 10.1016/j.pnpbp.2010.05.032ISI: 000281187800044PubMedID: 20570600OAI: diva2:404133
Available from: 2011-03-16 Created: 2011-03-16 Last updated: 2015-12-07

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